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1

L-735,524: An Orally Bioavailable Human Immunodeficiency Virus Type 1 Protease Inhibitor

J. P. Vacca, B. D. Dorsey, W. A. Schleif, R. B. Levin, S. L. McDaniel, P. L. Darke, J. Zugay, J. C. Quintero, O. M. Blahy, E. Roth, V. V. Sardana, A. J. Schlabach, P. I. Graham, J. H. Condra, L. Gotli

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.14 MB

english, 1994

2

L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

Vacca, J. P., Dorsey, B. D., Schleif, W. A., Levin, R. B., McDaniel, S. L., Darke, P. L., Zugay, J., Quintero, J. C., Blahy, O. M., Roth, E.

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.19 MB

english, 1994

3

A new hydroxyethylamine class of HIV-1 protease inhibitors with high antiviral potency and oral bioavailability

B.Moon Kim, Joseph P. Vacca, James P. Guare, Colleen M. Hanifin, Stuart R. Michelson, PaulL. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Jiunn H. Lin, I-Wu Chen, Kari Vastag, Drazen Ostovi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 463 KB

english, 1994

4

Thiophene derivatives as extremely high affinity P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors

B. Moon Kim, James P. Guare, Joseph D. Vacca, Stuart R. Michelson, Paul L. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Jiunn H. Lin, I.W. Chen, Kari Vastag, Paul S. Anderson, Joel R. Huff

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 297 KB

english, 1995

5

Substituted alkylpyridines as P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors: Improved pharmacokinetic profiles

B. Moon Kim, Colleen M. Hanifin, C. Blair Zartman, Joseph P. Vacca, Stuart R. Michelson, Jiunn H. Lin, I.-W. Chen, Kari Vastag, Paul L. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Paul S.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 277 KB

english, 1995

6

Cycloalkylpiperazines as HIV-1 protease inhibitors: enhanced oral absorption

B. Moon Kim, Ben E. Evans, Kevin F. Gilbert, Colleen M. Hanifin, Joseph P. Vacca, Stuart R. Michelson, Paul L. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Jiunn H. Lin, I.-W. Chen, Kari Va

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 287 KB

english, 1995

7

Stereoselective synthesis of the hydroxyethylene isostere of the HIV protease (Tyr-Pro) cleavage site

Wayne J. Thompson, Richard G. Ball, Paul L. Darke, Joan A. Zugay, J.E. Thies

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 246 KB

english, 1992

8

Novel conformationally constrained HIV-1 protease inhibitors: rational design, enzyme inhibition, and X-ray structure of an enzyme-inhibtor complex

B.Moon Kim, Joseph P. Vacca, Paula M.D. Fitzgerald, Paul L. Darke, M.Katharine Holloway, James P. Guare, Colleen M. Hanifin, Deborah J. Arford-Bickerstaff, Joan A. Zugay, Jenny M. Wai, Paul S. Anderso

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 2.01 MB

english, 1994

9

Potent HIV-1 protease inhibitors: stereoselective synthesis of a dipeptide mimic

Ghosh, Arun K., McKee, Sean P., Thompson, Wayne J., Darke, Paul L., Zugay, Joan C.

Journal:

Journal of Organic Chemistry

Year:

1993

Language:

english

File:

PDF, 624 KB

english, 1993

10

ChemInform Abstract: Substituted Alkylpyridines as P3′ Ligands for the Hydroxyethylpiperazine Class of HIV-1 Protease Inhibitors: Improved Pharmacokinetic Profiles.

B. M. KIM, C. M. HANIFIN, C. BLAIR ZARTMAN, J. P. VACCA, S. R. MICHELSON, J. H. LIN, I.-W. CHEN, K. VASTAG, P. L. DARKE, J. A. ZUGAY, E. A. EMINI, W. SCHLEIF, P. S. ANDERSON, J. R. HUFF

Journal:

Year:

1996

File:

PDF, 30 KB

1996

11

ChemInform Abstract: Nonpeptidal P2 Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation.

A. K. GHOSH, J. F. KINCAID, D. E. WALTERS, Y. CHEN, N. C. CHAUDHURI, W. J. THOMPSON, C. CULBERSON, P. M. D. FITZGERALD, H. Y. LEE, S. P. MCKEE, P. M. MUNSON, T. T. DUONG, P. L. DARKE, J. A. ZUGAY, W.

Journal:

Year:

1996

Language:

english

File:

PDF, 34 KB

english, 1996

12

X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293) - an initial glance of the viral DNA binding platform

Zhongguo Chen, Youwei Yan, Sanjeev Munshi, Ying Li, Joan Zugay-Murphy, Bei Xu, Marc Witmer, Peter Felock, Abigail Wolfe, Vinod Sardana, Emilio A Emini, Daria Hazuda, Lawrence C Kuo

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 858 KB

english, 2000

13

An Uniquely Purified HCV NS3 Protease and NS4A21–34 Peptide Form a Highly Active Serine Protease Complex in Peptide Hydrolysis

Vinod.V. Sardana, Jeffrey T. Blue, Joan Zugay-Murphy, Mohinder K. Sardana, Lawrence C. Kuo

Journal:

Protein Expression and Purification

Year:

1999

Language:

english

File:

PDF, 119 KB

english, 1999

14

A general procedure for the purification of human β-secretase expressed in Escherichia coli

Vinod Sardana, Bei Xu, Joan Zugay-Murphy, Zhongguo Chen, Mohinder Sardana, Paul L Darke, Sanjeev Munshi, Lawrence C Kuo

Journal:

Protein Expression and Purification

Year:

2004

Language:

english

File:

PDF, 410 KB

english, 2004

15

Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl design

Thompson, Wayne J., Fitzgerald, Paula M. D., Holloway, M. Katharine, Emini, Emilio A., Darke, Paul L., McKeever, Brian M., Schleif, William A., Quintero, Julio C., Zugay, Joan A.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 6.11 MB

english, 1992

16

A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity

Tucker, Thomas J., Lumma, William C., Payne, Linda S., Wai, Jenny M., De Solms, S. Jane, Giuliani, Elizabeth A., Darke, Paul L., Heimbach, Jill C., Zugay, Joan A.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.60 MB

english, 1992

17

L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor

Dorsey, Bruce D., Levin, Rhonda B., McDaniel, Stacy L., Vacca, Joseph P., Guare, James P., Darke, Paul L., Zugay, Joan A., Emini, Emilio A., Schleif, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 2.17 MB

english, 1994

18

Benzocycloalkyl amines as novel C-termini for HIV protease inhibitors

Lyle, Terry A., Wiscount, Catherine M., Guare, James P., Thompson, Wayne J., Anderson, Paul S., Darke, Paul L., Zugay, Joan A., Emini, Emilio A., Schleif, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 339 KB

english, 1991

19

Cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors

Ghosh, Arun K., Thompson, Wayne J., Lee, Hee Yoon, McKee, Sean P., Munson, Peter M., Duong, Tien T., Darke, Paul L., Zugay, Joan A., Emini, Emilio A.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 390 KB

english, 1993

20

Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors

Dorsey, Bruce D., McDonough, Colleen, McDaniel, Stacey L., Levin, Rhonda B., Newton, Christina L., Hoffman, Jacob M., Darke, Paul L., Zugay-Murphy, Joan A., Emini, Emilio A., Schleif, William A., Olse

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 228 KB

english, 2000

21

Dissociation and association of the HIV-1 protease dimer subunits: Equilibria and rates

Darke, Paul L., Hall, Dawn L., Jordan, Susan P., Zugay, Joan A., Shafer, Jules A., Kuo, Lawrence C.

Journal:

Year:

1994

Language:

english

File:

PDF, 989 KB

english, 1994

22

Only a Small Fraction of Purified Hepatitis C RNA-Dependent RNA Polymerase Is Catalytically Competent: Implications for Viral Replication and in Vitro Assays

Carroll, Steven S., Sardana, Vinod, Yang, Zhucheng, Jacobs, Amanda R., Mizenko, Christine, Hall, Dawn, Hill, Lorraine, Zugay-Murphy, Joan, Kuo, Lawrence C.

Journal:

Year:

2000

Language:

english

File:

PDF, 96 KB

english, 2000

23

3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors

Ghosh, Arun K., Thompson, Wayne J., McKee, Sean P., Duong, Tien T., Lyle, Terry A., Chen, Jenny C., Darke, Paul L., Zugay, Joan A., Emini, Emilio A.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 332 KB

english, 1993

24

3'-Tetrahydrofuranylglycine as a novel, unnatural amino acid surrogate for asparagine in the design of inhibitors of the HIV protease

Thompson, Wayne J., Ghosh, Arun K., Holloway, M. Katharine, Lee, Hee Yoon, Munson, Peter M., Schwering, John E., Wai, Jenny, Darke, Paul L., Zugay, Joan

Journal:

Journal of the American Chemical Society

Year:

1993

Language:

english

File:

PDF, 423 KB

english, 1993

25

Structure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton Transfer

Clayton, G. M., Klein, D. J., Rickert, K. W., Patel, S. B., Kornienko, M., Zugay-Murphy, J., Reid, J. C., Tummala, S., Sharma, S., Singh, S. B., Miesel, L., Lumb, K. J., Soisson, S. M.

Journal:

Journal of Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 2.44 MB

english, 2013

26

Structural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop Phosphorylation

Sunami, T., Byrne, N., Diehl, R. E., Funabashi, K., Hall, D. L., Ikuta, M., Patel, S. B., Shipman, J. M., Smith, R. F., Takahashi, I., Zugay-Murphy, J., Iwasawa, Y., Lumb, K. J., Munshi, S. K., Sharma

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 2.07 MB

english, 2010

27

Comparison of feed intake behavior between cool- and warm-season hays offered at restricted and ad libitum rates

Chizek, E.L., Hansen, T.L., Zugay, O.K., Warren, L.K.

Journal:

Journal of Equine Veterinary Science

Year:

2017

Language:

english

File:

PDF, 106 KB

english, 2017

28

Digestive characteristics of cool- and warm-season forages differing in fiber composition

Hansen, T.L., Chizek, E.L., Zugay, O.K., Warren, L.K.

Journal:

Journal of Equine Veterinary Science

Year:

2017

Language:

english

File:

PDF, 108 KB

english, 2017

29

Placing Research on Their Map: Curriculum Mapping as a Collaboration Tool for an Architecture Branch Library

Reed, Bonnie, Veeder, Hillary B., Schumacher, Sara, Zugay, Brian C. R.

Journal:

Art Documentation Journal of the Art Libraries Society of North America

Year:

2018

Language:

english

File:

PDF, 2.73 MB

english, 2018

30

Placing Research on Their Map: Curriculum Mapping as a Collaboration Tool for an Architecture Branch Library

Reed, Bonnie, Veeder, Hillary B., Schumacher, Sara, Zugay, Brian C. R.

Journal:

Art Documentation Journal of the Art Libraries Society of North America

Year:

2018

File:

PDF, 2.73 MB

2018

31

0811 Maturity of bermudagrass hay affects digestibility by horses

Hansen, T. L., Lee, E. C., Zugay, O. K., Warren, L. K.

Journal:

Journal of Animal Science

Year:

2016

Language:

english

File:

PDF, 258 KB

english, 2016

32

0811 Maturity of bermudagrass hay affects digestibility by horses

Hansen, T. L., Lee, E. C., Zugay, O. K., Warren, L. K.

Journal:

Journal of Animal Science

Year:

2016

File:

PDF, 258 KB

2016

33

Digestibility and Retention Time of Coastal Bermudagrass (Cynodon dactylon) Hay by Horses

Hansen, Tayler L., Chizek, Elisabeth L., Zugay, Olivia K., Miller, Jessica M., Bobel, Jill M., Chouinard, Jessie W., Adkin, Angie M., Skurupey, Leigh Ann, Warren, Lori K.

Journal:

Year:

2019

File:

PDF, 822 KB

2019

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